Natural selection of FLT1 alleles and their association with malaria resistance in utero
Natural selection of FLT1 alleles and their association with malaria resistance in utero
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Placental malaria (PM) caused by Plasmodium falciparum contributes significantly to infant mortality in sub-Saharan Africa and is associated with pregnancy loss. We hypothesized that fetal genes that modify PM would be associated with fetal fitness. During PM, placental trophoblasts produce soluble fms-like tyrosine kinase 1 (sFlt1), also known as...
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Full title
Natural selection of FLT1 alleles and their association with malaria resistance in utero
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TN_cdi_crossref_primary_10_1073_pnas_0803657105
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0803657105
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0803657105
