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Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0809084105

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

About this item

Full title

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (52), p.20683-20688

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Bacterial aromatic polyketides are important therapeutic compounds including front line antibiotics and anticancer drugs. It is one of the last remaining major classes of natural products of which the biosynthesis has not been reconstituted in the genetically superior host Escherichia coli. Here, we demonstrate the engineered biosynthesis of bacter...

Alternative Titles

Full title

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_0809084105

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0809084105

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0809084105

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