Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks
Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks
About this item
Full title
Author / Creator
Schäffer, Lauge , Brissette, Renee E. , Spetzler, Jane C. , Pillutla, Renuka C. , Østergaard, Søren , Lennick, Michael , Brandt, Jakob , Fletcher, Paul W. , Danielsen, Gillian M. , Hsiao, Ku-Chuan , Andersen, Asser S. , Dedova, Olga , Ribel, Ulla , Hoeg-Jensen, Thomas , Hansen, Per Hertz , Blume, Arthur J. , Markussen, Jan and Goldstein, Neil I.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Insulin is thought to elicit its effects by crosslinking the two extracellular α-subunits of its receptor, thereby inducing a conformational change in the receptor, which activates the intracellular tyrosine kinase signaling cascade. Previously we identified a series of peptides binding to two discrete hotspots on the insulin receptor. Here we show...
Alternative Titles
Full title
Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks
Authors, Artists and Contributors
Author / Creator
Brissette, Renee E.
Spetzler, Jane C.
Pillutla, Renuka C.
Østergaard, Søren
Lennick, Michael
Brandt, Jakob
Fletcher, Paul W.
Danielsen, Gillian M.
Hsiao, Ku-Chuan
Andersen, Asser S.
Dedova, Olga
Ribel, Ulla
Hoeg-Jensen, Thomas
Hansen, Per Hertz
Blume, Arthur J.
Markussen, Jan
Goldstein, Neil I.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_0830026100
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0830026100
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0830026100
