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Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway

Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0906885107

Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway

About this item

Full title

Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (6), p.2473-2478

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Multisite covalent modification of proteins is omnipresent in eukaryotic cells. A well-known example is the mi tog en-activated protein kinase (MAPK) cascade where, in each layer of the cascade, a protein is phosphorylated at two sites. It has long been known that the response of a MAPK pathway strongly depends on whether the enzymes that modify th...

Alternative Titles

Full title

Spatio-Temporal Correlations Can Drastically Change the Response of a MAPK Pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_0906885107

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0906885107

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0906885107

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