Ca v 1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations
Ca v 1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations
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Publisher
National Academy of Sciences
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Language
English
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Publisher
National Academy of Sciences
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Contents
Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and voltage-gated Ca²⁺ channel (Ca v 1.2) activity, and...
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Full title
Ca v 1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations
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TN_cdi_crossref_primary_10_1073_pnas_0913760107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_0913760107
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0913760107
