Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-indu...
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Both increase and decrease of cardiac inward rectifier current (I K1 ) are associated with severe cardiac arrhythmias. Flecainide, a widely used antiarrhythmic drug, exhibits ventricular proarrhythmic effects while effectively controlling ventricular arrhythmias associated with mutations in the gene encoding Kir2.1 channels that decrease I K1 (Ande...
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Full title
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1004021107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1004021107
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1004021107
