Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and at...
Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
A computational methodology based on Metropolis Monte Carlo (MC) and the weighted histogram analysis method (WHAM) has been developed to calculate the absolute binding free energy between functionalized nanocarriers (NC) and endothelial cell (EC) surfaces. The calculated NC binding free energy landscapes yield binding affinities that agree quantita...
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Full title
Computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and atomic force microscopy experiments
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1006611107
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1006611107
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1006611107
