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Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function i...

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Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function i...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1107103108

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans

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Full title

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans

Author / Creator

Pak, ChangHui , Garshasbi, Masoud , Kahrizi, Kimia , Gross, Christina , Apponi, Luciano H , Noto, John J , Kelly, Seth M , Leung, Sara W , Tzschach, Andreas , Behjati, Farkhondeh , Abedini, Seyedeh Sedigheh , Mohseni, Marzieh , Jensen, Lars R , Hu, Hao , Huang, Brenda , Stahley, Sara N , Liu, Guanglu , Williams, Kathryn R , Burdick, Sharon , Feng, Yue , Sanyal, Subhabrata , Bassell, Gary J , Ropers, Hans-Hilger , Najmabadi, Hossein , Corbett, Anita H , Moberg, Kenneth H and Kuss, Andreas W

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (30), p.12390-12395

Language

English

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Articles

Publication information

Publisher

United States: National Academy of Sciences

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Subjects and topics

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Scope and Contents

Contents

Here we report a human intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein. We identify ZC3H14 mRNA transcripts in the human central nervous system, and we find that rodent ZC3H14 protein is expressed in hippocampal neurons and colocalize...

Alternative Titles

Full title

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans

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Author / Creator

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Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_1107103108

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1107103108

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1107103108

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