Impaired phosphorylation of Na+-K+-2Cl– cotransporter by oxidative stress-responsive kinase-1 defici...
Impaired phosphorylation of Na+-K+-2Cl– cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Na+-K+-2Cl– cotransporters (NKCCs), including NKCC1 and renal-specific NKCC2, and the Na+-Cl– cotransporter (NCC) play pivotal roles in the regulation of blood pressure (BP) and renal NaCl reabsorption. Oxidative stress-responsive kinase-1 (OSR1) is a known upstream regulator of N(K)CCs. We generated and analyzed global and kidney tubule-specific (...
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Full title
Impaired phosphorylation of Na+-K+-2Cl– cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome
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TN_cdi_crossref_primary_10_1073_pnas_1107452108
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1107452108
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1107452108
