Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaterna...
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
About this item
Full title
Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Kwon, Young Do , Finzi, Andrés , Wu, Xueling , Dogo-Isonagie, Cajetan , Lee, Lawrence K , Moore, Lucas R , Schmidt, Stephen D , Stuckey, Jonathan , Yang, Yongping , Zhou, Tongqing , Zhu, Jiang , Vicic, David A , Debnath, Asim K , Shapiro, Lawrence , Bewley, Carole A , Mascola, John R , Sodroski, Joseph G and Kwong, Peter D
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The HIV-1 envelope (Env) spike (gp1203/gp413) undergoes considerable structural rearrangements to mediate virus entry into cells and to evade the host immune response. Engagement of CD4, the primary human receptor, fixes a particular conformation and primes Env for entry. The CD4-bound state, however, is prone to spontaneous inactivation and suscep...
Alternative Titles
Full title
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops
Authors, Artists and Contributors
Author / Creator
Kwon, Young Do
Finzi, Andrés
Wu, Xueling
Dogo-Isonagie, Cajetan
Lee, Lawrence K
Moore, Lucas R
Schmidt, Stephen D
Stuckey, Jonathan
Yang, Yongping
Zhou, Tongqing
Zhu, Jiang
Vicic, David A
Debnath, Asim K
Shapiro, Lawrence
Bewley, Carole A
Mascola, John R
Sodroski, Joseph G
Kwong, Peter D
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1112391109
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1112391109
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1112391109
