RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse...
RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient. Most SCNT-generated embryos die after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here we identify the most upstream level of dysfunction leading to impaired development of clones by using RNAi...
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Full title
RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos
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TN_cdi_crossref_primary_10_1073_pnas_1112664108
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1112664108
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1112664108
