CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated...
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
About this item
Full title
Author / Creator
Cantley, Jennifer L. , Yoshimura, Toru , Camporez, Joao Paulo G. , Zhang, Dongyan , Jornayvaz, Francois R. , Kumashiro, Naoki , Guebre-Egziabher, Fitsum , Jurczak, Michael J. , Kahn, Mario , Guigni, Bias A. , Serr, Julie , Hankin, Joseph , Murphy, Robert C. , Cline, Gary W. , Bhanot, Sanjay , Manchem, Vara Prasad , Brown, J. Mark , Samuel, Varman T. and Shulman, Gerald I.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Comparative gene identification 58 (CGI-58) is a lipid droplet-associated protein that promotes the hydrolysis of triglyceride by activating adipose triglyceride lipase. Loss-of-function mutations in CGI-58 in humans lead to Chanarin–Dorfman syndrome, a condition in which triglyceride accumulates in various tissues, including the skin, liver, muscl...
Alternative Titles
Full title
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
Authors, Artists and Contributors
Author / Creator
Yoshimura, Toru
Camporez, Joao Paulo G.
Zhang, Dongyan
Jornayvaz, Francois R.
Kumashiro, Naoki
Guebre-Egziabher, Fitsum
Jurczak, Michael J.
Kahn, Mario
Guigni, Bias A.
Serr, Julie
Hankin, Joseph
Murphy, Robert C.
Cline, Gary W.
Bhanot, Sanjay
Manchem, Vara Prasad
Brown, J. Mark
Samuel, Varman T.
Shulman, Gerald I.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1219456110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1219456110
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1219456110
