Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle matura...
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer interface at the binding site for the host protein lens epithelium-derived growth factor (LEDGF)/transcriptional coactivator p75 are an emerging class of small molecule...
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Full title
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1300703110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1300703110
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1300703110
