Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltra...
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatrie malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. This alteration is hypothesized to confer oncogenic dependency on EZH2 in these cancers. We report the discovery of a potent selective, and orally bioavailable small-m...
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Full title
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
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TN_cdi_crossref_primary_10_1073_pnas_1303800110
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1303800110
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1303800110
