Structures of human folate receptors reveal biological trafficking states and diversity in folate an...
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Antifolates, folate analogs that inhibit vitamin B ₉ (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of the antifolates in clinical use occurs primarily via widely expressed facilitative membrane transporters. More recently, human folate receptors (FRs),...
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Full title
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1308827110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1308827110
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1308827110
