Dimerization of LTβR by LTα 1 β 2 is necessary and sufficient for signal transduction
Dimerization of LTβR by LTα 1 β 2 is necessary and sufficient for signal transduction
About this item
Full title
Dimerization of LTβR by LTα 1 β 2 is necessary and sufficient for signal transduction
Author / Creator
Journal title
Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (49), p.19896-19901
Language
English
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Scope and Contents
Contents
Cytokines are proteins that modulate the activity of target cells via activation of cell-surface receptors. The trimeric cytokines of the tumor necrosis factor superfamily typically signal by inducing homotrimerization of their cognate receptors. We use structural and biophysical approaches to show that the unique heterotrimeric tumor necrosis fact...
Alternative Titles
Full title
Dimerization of LTβR by LTα 1 β 2 is necessary and sufficient for signal transduction
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1310838110
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1310838110
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1310838110
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