Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of co...
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Complement component C1, the complex that initiates the classical pathway of complement activation, is a 790-kDa assembly formed from the target-recognition subcomponent C1q and the modular proteases C1r and C1s. The proteases are elongated tetramers that become more compact when they bind to the collagen-like domains of C1q. Here, we describe a se...
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Full title
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
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TN_cdi_crossref_primary_10_1073_pnas_1311113110
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1311113110
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1311113110
