Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-depen...
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
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Author / Creator
Grad, Leslie I. , Yerbury, Justin J. , Turner, Bradley J. , Guest, William C. , Pokrishevsky, Edward , O'Neill, Megan A. , Yanai, Anat , Silverman, Judith M. , Zeineddine, Rafaa , Corcoran, Lisa , Kumita, Janet R. , Luheshi, Leila M. , Yousefi, Masoud , Coleman, Bradley M. , Hill, Andrew F. , Plotkin, Steven S. , Mackenzie, Ian R. and Cashman, Neil R.
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable genetic mutations in 5–10% of cases, including those in Cu/Zn superoxide dismutase (SOD1). We previously showed that misfolding of SOD1 can be transmitted to endogenous human wild-type SOD1 (HuWtSOD1) in an intracellular compartment. Using NSC-34 motor neur...
Alternative Titles
Full title
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
Authors, Artists and Contributors
Author / Creator
Yerbury, Justin J.
Turner, Bradley J.
Guest, William C.
Pokrishevsky, Edward
O'Neill, Megan A.
Yanai, Anat
Silverman, Judith M.
Zeineddine, Rafaa
Corcoran, Lisa
Kumita, Janet R.
Luheshi, Leila M.
Yousefi, Masoud
Coleman, Bradley M.
Hill, Andrew F.
Plotkin, Steven S.
Mackenzie, Ian R.
Cashman, Neil R.
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Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1312245111
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1312245111
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1312245111
