Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
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Author / Creator
Hu, Qi , Di Wu , Chen, Wen , Yan, Zhen , Yan, Chuangye , He, Tianxi , Liang, Qionglin and Shi, Yigong
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that the previously reported...
Alternative Titles
Full title
Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1418000111
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1418000111
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1418000111
