Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor
Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The neuromodulator dopamine signals through the dopamine D2 receptor (D₂R) to modulate central nervous system functions through diverse signal transduction pathways. D₂R is a prominent target for drug treatments in disorders where dopamine function is aberrant, such as schizophrenia. D₂R signals through distinct G-protein and β-arrestin pathways, a...
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Full title
Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_1502742112
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1502742112
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1502742112
