Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Since the linking of mutations in the Cu,Zn superoxide dismutase gene (sod1) to amyotrophic lateral sclerosis (ALS) in 1993, researchers have sought the connection between SOD1 and motor neuron death. Disease-linked mutations tend to destabilize the native dimeric structure of SOD1, and plaques containing misfolded and aggregated SOD1 have been fou...
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Full title
Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis
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TN_cdi_crossref_primary_10_1073_pnas_1516725113
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1516725113
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1516725113
