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Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1519273113

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

About this item

Full title

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (1), p.E16-E22

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Despite progress in systemic small interfering RNA (siRNA) delivery to the liver and to solid tumors, systemic siRNA delivery to leukocytes remains challenging. The ability to silence gene expression in leukocytes has great potential for identifying drug targets and for RNAi-based therapy for leukocyte diseases. However, both normal and malignant l...

Alternative Titles

Full title

Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_1073_pnas_1519273113

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_1519273113

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1519273113

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