Enhanced Antitumor Efficacy of a Herpes Simplex Virus Mutant Isolated by Genetic Selection in Cancer...
Enhanced Antitumor Efficacy of a Herpes Simplex Virus Mutant Isolated by Genetic Selection in Cancer Cells
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Replication-competent, attenuated herpes simplex virus-1 (HSV-1) derivatives that contain engineered mutations into the viral γ34.5 virulence gene have been used as oncolytic agents. However, as attenuated mutants often grow poorly, they may not completely destroy some tumors and surviving cancer cells simply regrow. Thus, although HSV-1 γ34.5 muta...
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Full title
Enhanced Antitumor Efficacy of a Herpes Simplex Virus Mutant Isolated by Genetic Selection in Cancer Cells
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TN_cdi_crossref_primary_10_1073_pnas_161011798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_161011798
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.161011798
