Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F 420...
Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F 420 H 2 -dependent reduction
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Publisher
United States
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Language
English
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United States
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Contents
Triaza-coumarin (TA-C) is a
(Mtb) dihydrofolate reductase (DHFR) inhibitor with an IC
(half maximal inhibitory concentration) of ∼1 µM against the enzyme. Despite this moderate target inhibition, TA-C shows exquisite antimycobacterial activity (MIC
, concentration inhibiting growth by 50% = 10 to 20 nM). Here, we investigated the mechanism...
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Full title
Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F 420 H 2 -dependent reduction
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TN_cdi_crossref_primary_10_1073_pnas_2025172118
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_2025172118
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2025172118
