The Activation Mechanism of Rat Vanilloid Receptor 1 by Capsaicin Involves the Pore Domain and Diffe...
The Activation Mechanism of Rat Vanilloid Receptor 1 by Capsaicin Involves the Pore Domain and Differs from the Activation by Either Acid or Heat
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United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin, acid, and heat. To determine the molecular mechanisms facilitating channel opening in response to these stimuli, VR1 and six channels containing charge neutralization point mutations surrounding the putative channel pore domain were expressed and characterized in Xenopu...
Alternative Titles
Full title
The Activation Mechanism of Rat Vanilloid Receptor 1 by Capsaicin Involves the Pore Domain and Differs from the Activation by Either Acid or Heat
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_230146497
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_230146497
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.230146497
