Mutational Spectrometry: A General Approach for Hot-Spot Point Mutations in Selectable Genes
Mutational Spectrometry: A General Approach for Hot-Spot Point Mutations in Selectable Genes
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Publisher
Washington, DC: National Academy of Sciences of the United States of America
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Language
English
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Washington, DC: National Academy of Sciences of the United States of America
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Contents
To observe point mutational spectra with a high degree of precision, independent large cultures of human lymphoblastoid cells were treated with a mutagen, benzo[a]pyrene diol epoxide, and mutants at the HPRT gene were selected en masse by 6-thioguanine resistance. An average of 1.6 * 1046-thioguanine-resistant mutants were created per experiment an...
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Full title
Mutational Spectrometry: A General Approach for Hot-Spot Point Mutations in Selectable Genes
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TN_cdi_crossref_primary_10_1073_pnas_89_10_4623
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_89_10_4623
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.89.10.4623
