Rat Growth Hormone Gene Introns Stimulate Nucleosome Alignment in vitro and in Transgenic Mice
Rat Growth Hormone Gene Introns Stimulate Nucleosome Alignment in vitro and in Transgenic Mice
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United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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United States: National Academy of Sciences of the United States of America
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Contents
Average hepatic expression (mRNA per cell per gene) of a metallothionein-rat growth hormone (rGH) gene with its natural introns was about 15-fold higher than an intronless version when tested in transgenic mice. We examined the idea that intron removal leads to an alteration in chromatin structure that might be responsible for this effect. Using an...
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Full title
Rat Growth Hormone Gene Introns Stimulate Nucleosome Alignment in vitro and in Transgenic Mice
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TN_cdi_crossref_primary_10_1073_pnas_92_17_7724
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_92_17_7724
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.92.17.7724
