RB and Hbrm Cooperate to Repress the Activation Functions of E2F1
RB and Hbrm Cooperate to Repress the Activation Functions of E2F1
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Full title
Author / Creator
Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Forced expression of the retinoblastoma (RB) gene product inhibits the proliferation of cells in culture. A major target of the RB protein is the S-phase-inducing transcription factor E2F1. RB binds directly to the activation domain of E2F1 and silences it, thereby preventing cells from entering S phase. To induce complete G1arrest, RB requires the...
Alternative Titles
Full title
RB and Hbrm Cooperate to Repress the Activation Functions of E2F1
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_94_21_11268
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_94_21_11268
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.94.21.11268
