Protection against Peroxynitrite-Induced Fibroblast Injury and Arthritis Development by Inhibition o...
Protection against Peroxynitrite-Induced Fibroblast Injury and Arthritis Development by Inhibition of Poly(ADP-Ribose) Synthase
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS-/-) and corresponding wild-type animals (PARS+/+), with the...
Alternative Titles
Full title
Protection against Peroxynitrite-Induced Fibroblast Injury and Arthritis Development by Inhibition of Poly(ADP-Ribose) Synthase
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Record Identifier
TN_cdi_crossref_primary_10_1073_pnas_95_7_3867
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1073_pnas_95_7_3867
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.95.7.3867
