Rational design and synthesis of 2-(1 H -indazol-6-yl)-1 H -benzo[d]imidazole derivatives as inhibit...
Rational design and synthesis of 2-(1 H -indazol-6-yl)-1 H -benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants
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Publisher
England
Journal title
Language
English
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Publisher
England
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Contents
Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1
-indazol-6-yl)-1
-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhibitors based on the structural optimisation of previous FLT3 inhibitors. Derivatives were synt...
Alternative Titles
Full title
Rational design and synthesis of 2-(1 H -indazol-6-yl)-1 H -benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants
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Record Identifier
TN_cdi_crossref_primary_10_1080_14756366_2021_2020772
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1080_14756366_2021_2020772
Other Identifiers
ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2021.2020772
