Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB$_1$ Receptor Knockou...
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB$_1$ Receptor Knockout Mice
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Publisher
American Society for the Advancement of Science
Journal title
Language
English
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Publisher
American Society for the Advancement of Science
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Contents
The function of the central cannabinoid receptor (CB$_1$) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB$_1$ receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the rein...
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Full title
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB$_1$ Receptor Knockout Mice
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TN_cdi_crossref_primary_10_1126_science_283_5400_401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1126_science_283_5400_401
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.283.5400.401
