Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons
Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons
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Full title
Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons
Author / Creator
Journal title
Science (American Association for the Advancement of Science), 2016-05, Vol.352 (6286)
Language
English
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Scope and Contents
Contents
SHANK3 is a widely expressed scaffolding protein that is enriched in postsynaptic specializations. In mutant mice, SHANK3 mutations cause autism-like behavioral changes and exhibit alterations in synaptic transmission. Yi
et al.
produced human neurons lacking SHANK3 but not other genes that are also involved in the autism-like disease Phelan-...
Alternative Titles
Full title
Autism-associated SHANK3 haploinsufficiency causes I h channelopathy in human neurons
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TN_cdi_crossref_primary_10_1126_science_aaf2669
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1126_science_aaf2669
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf2669
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