Structures of human Na v 1.7 channel in complex with auxiliary subunits and animal toxins
Structures of human Na v 1.7 channel in complex with auxiliary subunits and animal toxins
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Publisher
United States
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Language
English
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United States
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Contents
Voltage-gated sodium channel Na
1.7 represents a promising target for pain relief. Here we report the cryo-electron microscopy structures of the human Na
1.7-β1-β2 complex bound to two combinations of pore blockers and gating modifier toxins (GMTs), tetrodotoxin with protoxin-II and saxitoxin with huwentoxin-IV, both determined at overall res...
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Full title
Structures of human Na v 1.7 channel in complex with auxiliary subunits and animal toxins
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TN_cdi_crossref_primary_10_1126_science_aaw2493
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1126_science_aaw2493
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaw2493
