Dapagliflozin Exerts Adrenal Sympatholysis via G protein-Coupled Receptor Kinase-2 & Tyrosine Hydrox...
Dapagliflozin Exerts Adrenal Sympatholysis via G protein-Coupled Receptor Kinase-2 & Tyrosine Hydroxylase Downregulation
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English
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The sodium-glucose co-transporter (SGLT)-2 inhibitor dapagliflozin was recently reported to reduce renal tyrosine hydroxylase (TH) and norepinephrine levels, lowering blood pressure and preventing endothelial dysfunction, in a murine model of neurogenic hypertension. This suggested that dapagliflozin may combat sympathetic nervous system (SNS) hype...
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Dapagliflozin Exerts Adrenal Sympatholysis via G protein-Coupled Receptor Kinase-2 & Tyrosine Hydroxylase Downregulation
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TN_cdi_crossref_primary_10_1210_jendso_bvab048_1335
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_1210_jendso_bvab048_1335
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ISSN
2472-1972
E-ISSN
2472-1972
DOI
10.1210/jendso/bvab048.1335
