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Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates throu...

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates throu...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_86194_3

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

About this item

Full title

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

Journal title

eLife, 2024-12, Vol.12

Language

English

Formats

More information

Scope and Contents

Contents

Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation. Cellular proteostasis also depends on the overall composition of the proteome and numerous env...

Alternative Titles

Full title

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_7554_eLife_86194_3

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_86194_3

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.86194.3

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