SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic...
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
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Author / Creator
Flaherty, Stephen E , Bezy, Olivier , Paulhus, Brianna LaCarubba , Song, LouJin , Piper, Mary , Pang, Jincheng , Park, Yoson , Asano, Shoh , Lien, Yu-Chin , Griffin, John D , Robertson, Andrew , Opsahl, Alan , Shanthappa, Dinesh Hirenallur , Ahn, Youngwook , Pashos, Evanthia , Simmons, Rebecca A , Birnbaum, Morris J and Wu, Zhidan
Journal title
Language
English
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Contents
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the
Spag7
gene linked to metabolic dysfunction in mice. Here, we show that SPAG7 KO mice are born smaller and develop obesity and glucose intolerance in adulthood. This obesity does not stem from hyperphagia, but a decrease in energy ex...
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Full title
SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
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Record Identifier
TN_cdi_crossref_primary_10_7554_eLife_91114_3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_91114_3
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.91114.3
