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Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion an...

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion an...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_91716_4

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

About this item

Full title

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

Journal title

eLife, 2025-01, Vol.12

Language

English

Formats

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Scope and Contents

Contents

Orexin signaling in the ventral tegmental area and substantia nigra promotes locomotion and reward processing, but it is not clear whether dopaminergic neurons directly mediate these effects. We show that dopaminergic neurons in these areas mainly express orexin receptor subtype 1 (Ox1R). In contrast, only a minor population in the medial ventral t...

Alternative Titles

Full title

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_crossref_primary_10_7554_eLife_91716_4

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_91716_4

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.91716.4

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