Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem p...
Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
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English
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Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly understood. Here, we generated a single-nucleus atlas of the periosteum at steady state and of the fracture site during the early stages of bone repair (
https://fracture-repair-atlas.cells.ucsc.edu
). We identified periosteal SSPCs expressing stemness markers (
Pi16
and
Ly6a
/SCA1) and responding to fracture by adopting an injury-induced fibrogenic cell (IIFC) fate, prior to undergoing osteogenesis or chondrogenesis. We identified distinct gene cores associated with IIFCs and their engagement into osteogenesis and chondrog...
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Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
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TN_cdi_crossref_primary_10_7554_eLife_92519_3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_92519_3
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.92519.3
