A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neu...
A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome
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Author / Creator
Zhao, Xingsen , Sun, Qihang , Shou, Yikai , Chen, Weijun , Wang, Mengxuan , Qu, Wenzheng , Huang, Xiaoli , Li, Ying , Wang, Chao , Gu, Yan , Ji, Chai , Shu, Qiang and Li, Xuekun
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English
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Contents
Williams syndrome (WS; OMIM#194050) is a rare disorder, which is caused by the microdeletion of one copy of 25–27 genes, and WS patients display diverse neuronal deficits. Although remarkable progresses have been achieved, the mechanisms for these distinct deficits are still largely unknown. Here, we have shown that neural progenitor cells (NPCs) i...
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Full title
A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome
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TN_cdi_crossref_primary_10_7554_eLife_98081_2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_crossref_primary_10_7554_eLife_98081_2
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.98081.2
