Parkinson"s disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and s...
Parkinson"s disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6
About this item
Full title
Author / Creator
Publisher
Public Library of Science (PLoS)
Journal title
Language
English
Formats
Publication information
Publisher
Public Library of Science (PLoS)
Subjects
More information
Scope and Contents
Contents
Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson"s disease (PD). Although large gene deletions have been linked to a loss-of-function phenotype, the pathogenic mechanism of missense mutations is less clear. The L166P mutation causes misfolding of DJ-1 protein and its degradation. L166P protein may al...
Alternative Titles
Full title
Parkinson"s disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_csuc_recercat_oai_recercat_cat_2072_222437
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_csuc_recercat_oai_recercat_cat_2072_222437
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
