Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
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Author / Creator
Cammareri, Patrizia , Rose, Aidan M. , Vincent, David F. , Wang, Jun , Nagano, Ai , Libertini, Silvana , Ridgway, Rachel A. , Athineos, Dimitris , Coates, Philip J. , McHugh, Angela , Pourreyron, Celine , Dayal, Jasbani H. S. , Larsson, Jonas , Weidlich, Simone , Spender, Lindsay C. , Sapkota, Gopal P. , Purdie, Karin J. , Proby, Charlotte M. , Harwood, Catherine A. , Leigh, Irene M. , Clevers, Hans , Barker, Nick , Karlsson, Stefan , Pritchard, Catrin , Marais, Richard , Chelala, Claude , South, Andrew P. , Sansom, Owen J. , Inman, Gareth J. , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , StemTherapy: National Initiative on Stem Cells for Regenerative Therapy , Department of Laboratory Medicine , Strategic research areas (SRA) , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Lund University , Division of Molecular Medicine and Gene Therapy , Institutionen för laboratoriemedicin , Profile areas and other strong research environments and Avdelningen för molekylärmedicin och genterapi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify frequent
TGFBR1
and
TGFBR2
mutations in human vemurafenib-induced skin lesions and in sporadic cSCC. Functional analysis reveals...
Alternative Titles
Full title
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Authors, Artists and Contributors
Author / Creator
Rose, Aidan M.
Vincent, David F.
Wang, Jun
Nagano, Ai
Libertini, Silvana
Ridgway, Rachel A.
Athineos, Dimitris
Coates, Philip J.
McHugh, Angela
Pourreyron, Celine
Dayal, Jasbani H. S.
Larsson, Jonas
Weidlich, Simone
Spender, Lindsay C.
Sapkota, Gopal P.
Purdie, Karin J.
Proby, Charlotte M.
Harwood, Catherine A.
Leigh, Irene M.
Clevers, Hans
Barker, Nick
Karlsson, Stefan
Pritchard, Catrin
Marais, Richard
Chelala, Claude
South, Andrew P.
Sansom, Owen J.
Inman, Gareth J.
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Department of Laboratory Medicine
Strategic research areas (SRA)
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Lund University
Division of Molecular Medicine and Gene Therapy
Institutionen för laboratoriemedicin
Profile areas and other strong research environments
Avdelningen för molekylärmedicin och genterapi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_007e4295faa9467ba2f947c4d342dc0a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_007e4295faa9467ba2f947c4d342dc0a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12493
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