Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils...
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
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England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable model of lipotoxicity, reproducing features of β-cell failure observed in type 2 diabetes. In order to map the β-cell resp...
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Full title
Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity
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TN_cdi_doaj_primary_oai_doaj_org_article_00865dcdc6ad4d628c3c9db3fbad1e00
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_00865dcdc6ad4d628c3c9db3fbad1e00
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ISSN
1471-2164
E-ISSN
1471-2164
DOI
10.1186/s12864-020-07003-0
