Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid level...
Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Gene editing has emerged as an exciting therapeutic development platform for numerous genetic and nongenetic diseases. Targeting lipid-modulating genes such as angiopoietin-related protein 3 (ANGPTL3) with gene editing offers hope for a permanent solution to lower cardiovascular disease risks associated with hypercholesterolemia.
In this study,...
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Full title
Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_01189687d1df469ca9f410bb5526ff84
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_01189687d1df469ca9f410bb5526ff84
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ISSN
2045-3701
E-ISSN
2045-3701
DOI
10.1186/s13578-023-01036-0
