Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degr...
Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that function in pathways critical to cancer cell growth. Tankyrase-mediated PARylation marks protein targets for proteasomal degradation. Here, we generate human knockout cell lines to examine cell function and interrogate the proteome. We show that either tankyrase 1 or 2 is sufficient to maintai...
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Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
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TN_cdi_doaj_primary_oai_doaj_org_article_013778b4668542dcb7be9914663032bd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_013778b4668542dcb7be9914663032bd
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02363-w
