RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of P...
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
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Author / Creator
Guo, Xingya , Li, Kai , Jiang, Weiliang , Hu, Yangyang , Xiao, Wenqin , Huang, Yinshi , Feng, Yun , Pan, Qin and Wan, Rong
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Contents
N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This study aimed to explore the role of the m6A demethylase ALKBH5 in pancreatic cancer (PC).
The expression of ALKBH5 and its clinicopathological impact were evaluated in PC cohorts. The effects of AL...
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Full title
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_01d86b852e8948cc86f1b160c8316a21
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_01d86b852e8948cc86f1b160c8316a21
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-020-01158-w
