Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility...
Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability
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Author / Creator
Xu, Zhuomin , Zheng, Shanshan , Gao, Xin , Hong, Yulu , Cai, Yue , Zhang, Qiuqin , Xiang, Jiani , Xie, Dehui , Song, Fuxing , Zhang, Huawei , Wang, Hong and Sun, Xuanrong
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Chrysomycin A (CA) has been reported as numerous excellent biological activities, such as antineoplastic and antibacterial. Though, poor solubility of CA limited its application in medical field. Due to good amphiphilicity and potential anticancer effect of disodium glycyrrhizin (Na
GA) as an excipient, an amorphous solid dispersion (Na
GA/CA...
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Full title
Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability
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TN_cdi_doaj_primary_oai_doaj_org_article_021315b96f4b4537b8d040fdade6d94b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_021315b96f4b4537b8d040fdade6d94b
Other Identifiers
ISSN
1477-3155
E-ISSN
1477-3155
DOI
10.1186/s12951-021-00911-7
