Similar excitability through different sodium channels and implications for the analgesic efficacy o...
Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Nociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel Na
1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical trials seeking to treat pain by inhibiting Na
1.7 pharmacologically have struggled. This may...
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Full title
Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs
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TN_cdi_doaj_primary_oai_doaj_org_article_022bf517b38c4c24ac1938e717b1fb83
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_022bf517b38c4c24ac1938e717b1fb83
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.90960
