FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8...
FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice
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Author / Creator
Irisarri, Alba , Corral, Ana , Perez-Salvador, Núria , Bellver-Sanchis, Aina , Ribalta-Vilella, Marta , Bentanachs, Roger , Alegret, Marta , Laguna, Juan Carlos , Barroso, Emma , Palomer, Xavier , Ortuño-Sahagún, Daniel , Vázquez-Carrera, Manuel , Pallàs, Mercè , Herrero, Laura and Griñán-Ferré, Christian
Publisher
England: Springer
Journal title
Language
English
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Publisher
England: Springer
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Scope and Contents
Contents
This study investigated the effects of fat mass and obesity-associated (FTO) inhibition on cognitive function and metabolic parameters of senescence-accelerated mouse prone 8 (SAMP8) mice fed a high-fat diet (HFD). SAMP8 mice fed an HFD exhibited increased body weight, impaired glucose tolerance, and elevated serum leptin levels. In epididymal whit...
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Full title
FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0232efad215d42fb82d43f6de5d5fe57
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0232efad215d42fb82d43f6de5d5fe57
Other Identifiers
ISSN
1528-3658
E-ISSN
1528-3658
DOI
10.1186/s10020-025-01126-4
