Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury
Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury
About this item
Full title
Author / Creator
Bhattacharya, Sabyasachi , Katlinski, Kanstantsin V , Reichert, Maximilian , Takano, Shigetsugu , Brice, Angela , Zhao, Bin , Yu, Qiujing , Zheng, Hui , Carbone, Christopher J , Katlinskaya, Yuliya V , Leu, N Adrian , McCorkell, Kelly A , Srinivasan, Satish , Girondo, Melanie , Rui, Hallgeir , May, Michael J , Avadhani, Narayan G , Rustgi, Anil K and Fuchs, Serge Y
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitination and downregulation thereby attenuating IFN effects
in vitro
. The significance of this paradoxical...
Alternative Titles
Full title
Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury
Authors, Artists and Contributors
Author / Creator
Katlinski, Kanstantsin V
Reichert, Maximilian
Takano, Shigetsugu
Brice, Angela
Zhao, Bin
Yu, Qiujing
Zheng, Hui
Carbone, Christopher J
Katlinskaya, Yuliya V
Leu, N Adrian
McCorkell, Kelly A
Srinivasan, Satish
Girondo, Melanie
Rui, Hallgeir
May, Michael J
Avadhani, Narayan G
Rustgi, Anil K
Fuchs, Serge Y
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_023f6fcb1025437991143748532942e5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_023f6fcb1025437991143748532942e5
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.1002/emmm.201303236
