Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Resp...
Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies
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Author / Creator
Beider, Katia , Itzhaki, Orit , Schachter, Jacob , Grushchenko-Polaq, Ania Hava , Voevoda-Dimenshtein, Valeria , Rosenberg, Evgenia , Ostrovsky, Olga , Devillers, Olivia , Shapira Frommer, Ronnie , Zeltzer, Li-at , Toren, Amos , Jacoby, Elad , Shimoni, Avichai , Avigdor, Abraham , Nagler, Arnon and Besser, Michal J.
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
Despite the high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, its full capacity is currently limited by the generation of dysfunctional CAR T cells. Senescent or exhausted CAR T cells possess poor targeting and effector functions, as well as impaired cell proliferation and persistence in vivo. Strategies to...
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Full title
Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies
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TN_cdi_doaj_primary_oai_doaj_org_article_02514ef3cdbe4b41b2bc1bbc9123ee34
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_02514ef3cdbe4b41b2bc1bbc9123ee34
Other Identifiers
ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells11071140
